Bruker introduces nVista 2P miniature microscope (2025)

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Bruker Corporationtoday announced the launch of thenVista2Pminiature, two-photon microscope, a groundbreaking addition to the Inscopix product line for functional imaging of freely behaving animals. It leverages advanced two-photon fluorescence microscopy technology to enable high-resolution imaging at greater depths with 3D data reconstruction, providing researchers with unprecedented insights into neuronal activity. Featuring several innovations in miniscope design,nVista2Poffers enhanced resolution for sub-cellular imaging and mapping of neural circuit dynamics.

ThenVista2Pminiscope is a self-contained, complete microscope that weighs only about 2grams. This system offers single-cell resolution with imaging depths up to 300microns to enable detailed exploration of densely labelled and deep regions, such as the entorhinal cortex and hypothalamus. The system is ideal for investigating disease models and key processes (e.g., spatial memory and neurotransmitter signaling). It is compatible with both shallow and deep GRIN lens applications and cranial window preparations, targeting all regions of a rodent’s brain with the same protocols used in one-photon experiments.

The 2P miniscope’s lightweight, compact, and adaptable design, paired with its thoughtfully crafted, intuitive interface, ensures exceptional ease of use,”

MostafizurRahman, Postdoctoral Fellow, DulacLab, HarvardUniversity

“It significantly advances our ability to address compelling scientific questions. Having previously relied on the Inscopix 1P miniscope, we have experienced a seamless transition to the 2P miniscope, further amplifying its value as a powerful tool for ourresearch.”

“The introduction ofnVista2Pmarks a major step forward in free-roaming miniscope innovation that complements Bruker’s industry-leading benchtop Ultima multiphoton microscope technology,” added KunalGhosh,Ph.D., CEO at Inscopix. “The unique ability of this new system to acquire high-resolution brain data in three dimensions, and its seamless integration with our exclusive sample preparation-to-results workflows, make it an ideal tool for researchers studying neuronal circuits in freely-behaving animals.”

AboutnVista 2P

ThenVista 2Pminiscope features full field-of-view acquisition at up to 15Hertz over a 400x400‑micron area, with the ability to target focal planes between 0- and 300‑microns working distance. The system integrates into the full Inscopix ecosystem with unique ProView Integrated 2P Lenses, the nVision behavioral acquisition unit, the IDEAS platform (including suite2p and CalmAn for specialized two-photon calcium imaging analysis), and Inscopix Data Processing Software (IDPS). In addition,nVista2Pis compatible with third-party accessories through TTL communication. The hardware is packaged on a carrier for easy transport between behavioral setups and requires a single power source. ThenVista2Pminiscope comes completely ready to use and provides high-quality data within the first day, integrating seamlessly with users’ routine workflows, all backed by Inscopix’s leading scientific support team.

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